Anaphylactic reaction to chymopapain injection: A review and anesthesia considerations
نویسندگان
چکیده
The Food and Drug Administration (FDA) recently has re-released chymopapain, an injectable proteolytic enzyme used as an alternative to lumbar laminectomy in selected patients. The reported success rate, over 800%, has inspired an increasing usage of chymopapain. However, there is a reported 1 % incidence of anaphylaxis upon injection of this drug. The authors describe the means of early recognition of signs and symptoms of anaphylaxis. A suggested anesthetic plan is presented that includes a protocol for management of anaphylaxis.
منابع مشابه
Test Evaluation
Chymopapain chemonucleolysis has become a viable option in the treatment of lumbar discs failing to respond to conservative therapy. The efficacy has been demonstrated in recent double-blind studies (1,2). Although relatively safe, occasional patients will exhibit an anaphylactic shock-like reaction upon injection of chymopapain. The reported incidence of anaphylaxis ranges from 0.18% to 1.0% (...
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